Observe Closely (1)phenobarbital will minimize the level or impact of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to your reduce in fentanyl plasma concentrations, insufficient efficacy or, perhaps, growth of a with… Read More